Measuring diffusion of xenon in solution with hyperpolarized Xe NMR
نویسندگان
چکیده
129 Ž . A hyperpolarized Xe Nuclear Magnetic Resonance NMR technique for measuring diffusion of xenon in solution is presented. The dramatically enhanced NMR signal of hyperpolarized Xe makes it possible to measure the xenon self-diffusion coefficient with a single-shot NMR experiment. Diffusion constants of xenon in various solvents are reported. Ž . y5 2 y1 A value of 2.2"0.4 =10 cm s was measured for xenon in water at room temperature. The potential applications of this technique to in vivo experiments are discussed. q 1998 Elsevier Science B.V. All rights reserved.
منابع مشابه
Xenon Surface Relaxivity: Potential Applications to Probing Lung Disease
Introduction Because hyperpolarized Xe gas NMR signals can result in four to five orders of magnitude polarization enhancement compared to thermal equilibrium signals even at high fields , hyperpolarized Xe gas MRI has shown great promise for lung imaging. Scientists have developed many techniques to assess lung properties, such as ADC (apparent diffusion coefficient) , XTC (Xenon polarization ...
متن کاملExploring surfaces and cavities in lipoxygenase and other proteins by hyperpolarized xenon-129 NMR.
This paper presents an exploratory study of the binding interactions of xenon with the surface of several different proteins in the solution and solid states using both conventional and hyperpolarized (129)Xe NMR. The generation of hyperpolarized (129)Xe by spin exchange optical pumping affords an enhancement by 3-4 orders of magnitude of its NMR signal. As a result, it is possible to observe X...
متن کاملNanoemulsion contrast agents with sub-picomolar sensitivity for xenon NMR.
A new type of contrast agent for Xe NMR based on surfactant-stabilized perfluorocarbon-in-water nanoemulsions has been produced. The contrast agent uses dissolved hyperpolarized xenon gas as a nonperturbing reporting medium, as xenon freely exchanges between aqueous solution and the perfluorocarbon interior of the droplets, which are spectroscopically distinguishable and allow for chemical exch...
متن کاملCucurbit[6]uril is an ultrasensitive (129)Xe NMR contrast agent.
A lack of molecular contrast agents has slowed the application of ultrasensitive hyperpolarized (129)Xe NMR methods. Here, we report that commercially available cucurbit[6]uril (CB[6]) undergoes rapid xenon exchange kinetics at 300 K, and is detectable by Hyper-CEST NMR at 1.8 pM in PBS and at 1 μM in human plasma where many molecules, including polyamines, can compete with xenon for CB[6] bind...
متن کاملMobile high resolution xenon nuclear magnetic resonance spectroscopy in the earth's magnetic field.
Conventional high resolution nuclear magnetic resonance (NMR) spectra are usually measured in homogeneous, high magnetic fields (>1 T), which are produced by expensive and immobile superconducting magnets. We show that chemically resolved xenon (Xe) NMR spectroscopy of liquid samples can be measured in the Earth's magnetic field (5 x 10(-5) T) with a continuous flow of hyperpolarized Xe gas. It...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 1998